In a study reported in WUSL The Source, researchers found that certain viruses that target the nervous system in the brain and spinal cord also can kill neurons in the guts of mice, disrupting bowel movement and causing intestinal blockages, leading people to unpredictable bouts of abdominal pain and constipation. While the research focused on West Nile and Zika virus, there may be other viruses that cause similar issues.
“There are a number of people who are otherwise healthy who suddenly develop bowel motility problems, and we don’t understand why,” said Thaddeus S. Stappenbeck, MD, PhD, the Conan Professor of Laboratory and Genomic Medicine and the study’s co-senior author. “But now we believe that one explanation could be that you can get a viral infection that results in your immune cells killing infected neurons in your gut. That might be why all of a sudden you can’t move things along any more.”
From the article, "Further investigation showed that West Nile virus, when injected into a mouse’s foot, travels through the bloodstream and infects neurons in the intestinal wall. These neurons coordinate muscle contractions to move waste smoothly through the gut. Once infected, the neurons attract the attention of immune cells, which attack the viruses – and kill the neurons in the process."
The Source - Washington University in St. Louis
Medicine & Health
https://source.wustl.edu/2018/10/viruses-in-blood-lead-to-digestive-problems/
Viruses in blood lead to digestive problems
Mouse study provides clues to sudden onset of digestive woes
By Tamara Bhandari • October 4, 2018