There have been 11 cases of human plague with 3 deaths. Cases are based in western US and are associated with the fleas, often those found on squirrels or other rodents.
"Plague circulates among wild rodents and their fleas in rural and semirural areas in the western United States (2). Transmission to humans occurs through the bite of infected fleas, direct contact with infected body fluids or tissues, or inhalation of respiratory droplets from ill persons or animals, including ill domesticated cats and dogs (3). The usual incubation period between exposure and illness onset is 2–6 days."
A 2012 case occurred in Oregon where a man wrestled a dead rat out of a cat's mouth. From that posting: Yersinia pestis, a gram negative organism, is one of the most pathogenic organisms known. It can infect through lesions in the skin (such as a flea bite) where it infects the lymphnodes and then invades other organs where it causes massive tissue destruction. Gangrene often sets in on the dead tissue. It can also spread through inhalation of infective respiratory particles (pneumonia). Disease is initially characterized by development of one or more inflamed, swollen lymph nodes (buboes), and then chills and fever, lethargy and confusion. Historically, the fatality rate was greater than 50%, but now with antibiotics, it is 16% (below).
CDC - MMWR
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm64e0825a1.htm?s_cid=mm64e0825a1_e
Human Plague — United States, 2015
Early Release
August 25, 2015 / 64(Early Release);1-2
Natalie Kwit, DVM1,2; Christina Nelson, MD2; Kiersten Kugeler, PhD2; Jeannine Petersen, PhD2; Lydia Plante, MSPH3; Hayley Yaglom, MPH3; Vicki Kramer, PhD4; Benjamin Schwartz, MD5; Jennifer House, DVM6; Leah Colton, PhD6; Amanda Feldpausch, MPH7; Cherie Drenzek, DVM7; Joan Baumbach, MD8; Mark DiMenna, PhD9; Emily Fisher, MD1,10; Emilio Debess, DVM10; Danielle Buttke, DVM11; Matthew Weinburke, MPH11; Christopher Percy, MD12; Martin Schriefer, PhD2; Ken Gage, PhD2; Paul Mead, MD2
Since April 1, 2015, a total of 11 cases of human plague have been reported in residents of six states: Arizona (two), California (one), Colorado (four), Georgia (one), New Mexico (two), and Oregon (one). The two cases in Georgia and California residents have been linked to exposures at or near Yosemite National Park in the southern Sierra Nevada Mountains of California. Nine of the 11 patients were male; median age was 52 years (range = 14–79 years). Three patients aged 16, 52, and 79 years died.
Plague is a rare, life-threatening, flea-borne zoonosis caused by the bacterium Yersinia pestis. During 2001–2012, the annual number of human plague cases reported in the United States ranged from one to 17 (median = three cases) (1). It is unclear why the number of cases in 2015 is higher than usual. Plague circulates among wild rodents and their fleas in rural and semirural areas in the western United States (2). Transmission to humans occurs through the bite of infected fleas, direct contact with infected body fluids or tissues, or inhalation of respiratory droplets from ill persons or animals, including ill domesticated cats and dogs (3). The usual incubation period between exposure and illness onset is 2–6 days.
In humans, plague is characterized by the sudden onset of fever and malaise, which can be accompanied by abdominal pain, nausea, and vomiting. There are three main forms of plague, depending upon the route of infection. Bubonic plague, resulting from the bite of an infected flea, accounts for approximately 80%–85% of cases; patients develop a "bubo," a painful swelling of one or several lymph nodes that progresses during the first few days of illness. Septicemic plague, accounting for approximately 10% of cases, can occur from a flea bite or from direct contact with infectious fluids; infection spreads directly through the bloodstream with no localizing signs. Primary pneumonic plague, occurring in approximately 3% of plague patients, results from aerosol exposure to infective droplets and is characterized by a fulminant primary pneumonia. Secondary pneumonic plague can result from the spread of Y. pestis to the lungs in patients with untreated bubonic or septicemic infection.
The mortality rate for untreated plague has ranged from 66% to 93%; however, in the antibiotic era, mortality has been reduced to approximately 16% (4). Prompt treatment with antimicrobials such as aminoglycosides, fluoroquinolones, or doxycycline greatly improves outcome (4).
Health care providers should consider the diagnosis of plague in any patient with compatible signs or symptoms, residence or travel in the western United States, and recent proximity to rodent habitats or direct contact with rodents or ill domestic animals. Suspicion of plague should prompt 1) collection of blood, bubo aspirate, or sputum samples for Y. pestis diagnostic testing; 2) implementation of isolation and respiratory droplet precautions for patients with respiratory involvement; 3) immediate antibiotic treatment (before laboratory confirmation); and 4) notification of public health officials. Y. pestis–specific testing is available at state health laboratories. Recommendations for diagnostic testing and antibiotic treatment are available at http://www.cdc.gov/plague/healthcare/clinicians.html. Misidentification of Y. pestis as Pseudomonas luteola and other organisms through the use of automated bacterial identification systems has been reported (5).
Persons engaging in outdoor activities in areas where plague is endemic should wear long pants when possible and use insect repellent on clothing and skin. Persons also should avoid direct contact with ill or dead animals and never feed squirrels, chipmunks, or other rodents. In addition, pet owners should regularly use flea control products on their pets and consult a veterinarian if their pet is ill. Rodent habitat can be reduced around the home by removing brush, clutter, and potential rodent food sources such as garbage or pet food. Additional information on prevention of plague is available at http://www.cdc.gov/plague/prevention/index.html.
1Epidemic Intelligence Service, CDC; 2Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC; 3Arizona Department of Health Services; 4California Department of Public Health; 5Los Angeles County Department of Public Health, California; 6Colorado Department of Public Health and Environment; 7Georgia Department of Public Health; 8New Mexico Department of Health; 9Albuquerque Environmental Health Department, New Mexico; 10Oregon Health Authority; 11National Park Service; 12Navajo Area Indian Health Service.
Corresponding author: Natalie Kwit, nkwit@cdc.gov, 970-266-3587.
References
Adams DA, Jajosky RA, Ajani U, et al. Summary of notifiable diseases—United States, 2012. MMWR Morb Mortal Wkly Rep 2014;61:1–121.
CDC. Plague. Atlanta, GA: US Department of Health and Human Services, CDC; 2015. Available at http://www.cdc.gov/plague/.
Runfola JK, House J, Miller L, et al. Outbreak of human pneumonic plague with dog-to-human and possible human-to-human transmission—Colorado, June–July 2014. MMWR Morb Mortal Wkly Rep 2015;64:429–34.
Kugeler KJ, Staples JE, Hinckley AF, Gage KL, Mead PS. Epidemiology of human plague in the United States, 1900–2012. Emerg Infect Dis 2015;21:16–22.
CDC. Notes from the field: two cases of human plague—Oregon, 2010. MMWR Morb Mortal Wkly Rep 2011;60:214.
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